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InTouch Magazine - Spring/Summer 2002

Research: The Vision for Research at the Minneapolis Heart Institute Foundation

The Minneapolis Heart Institute Foundation is one of the nation’s premiere cardiovascular research facilities committed to improving patient care. Research is an essential scientific tool to promote leading edge therapy and diagnostic methods for our patients.

Dedicated and talented researchers carry out our "research mission" by expanding the bounds of patient knowledge, discovering new therapies and developing new technologies. Our research efforts enable discovery and innovation of new and emerging medical care for our patients by shared efforts within our Clinical and Pre-Clinical Research departments. Drs. Timothy Henry and Robert Schwartz have recently joined the Minneapolis Heart Institute Foundation as Director of Clinical and Pre-Clinical Research, respectively.

Dr. Timothy Henry – Director, Clinical Research

Dr. Timothy Henry"I want the Minneapolis Heart Institute Foundation to be the preeminent research institute in the United States," says Dr. Henry. "We already have a large volume of well-cared for patients at the Minneapolis Heart Institute (MHI). I’d like to have that same profile with our research."

Studies have shown that patients involved in research trials do better simply because they are a part of a study. We want our patients to be able to choose the option of a clinical research trial as a part of their plan of care. The Minneapolis Heart Institute is dedicated to offering the best in cardiology care to our patients. As a part of a vast research network we can offer the latest medical treatments and devices as they are being developed. These trials provide treatment options available only to MHI patients. "My hope is to have trials available for almost every patient group at MHI," says Dr. Henry. In order to do that we need to offer a wide variety of research studies.

So, how do we choose which studies to do? As research director, Dr. Henry takes great care in how he chooses a research study. He asks the following questions of each:

  • Is the question being asked scientifically valid? In other words, does this represent cutting edge technology and/or is this an important clinical question to answer?
  • Is this safe? All studies must pass the "mother test", according to Dr Henry. In other words, would you put your mother into this study? If not, we don’t do it.
  • Is this important professionally?

Ideally, each study we participate in will score high on all three points. The "mother test" is essential. A number of other issues impact our decision to participate in a trial. It is essential that we provide high quality data and honor our commitments in a trial. Therefore, our goal is to always be one of the top performing sites in a clinical trial.

Clinical trials focus on finding the causes of heart disease or on the treatments for heart disease. As a part of Dr. Henry’s plan to have research trials available for all patient care groups, the following research centers have been or will be formed within the Minneapolis Heart Institute Foundation:

Acute Coronary Syndromes – The study of unstable angina or heart attacks caused by blockages in the heart (coronary artery disease) which rupture and form blood clots.

Angiogenesis/No-Option Patients – The study of patients who have coronary artery disease and angina and who can no longer have bypass or angioplasty.

Cardiac Imaging – Techniques for viewing the heart such as MRI, nuclear cardiology, CT scan, echocardiography.

Cardiovascular Surgery – The study of new techniques, devices or medications to give along with surgery on coronary arteries or heart valves.

Congestive Heart Failure – Treatments for patients with heart muscle damage.

Electrophysiology – The study of disturbances of the heart rhythm.

Hypertrophic Cardiomyopathy – The study of inherited heart muscle disease.

Integrative Medicine – Studies looking at the health of body, mind and spirit.

Interventional Cardiology – The study of non-surgical treatments, such as angioplasty, stents or medicines, for blockages of the coronary arteries.

Peripheral Vascular Disease – The study of treatments for blockages in the arteries of the legs.

Preventive Cardiology – Studies to prevent heart disease and to prevent future events.

In summary, the clinical research program at the Minneapolis Heart Institute Foundation is geared towards offering new and effective therapies to our patients, while at the same time answering important clinical cardiology questions in order to provide the best care to our patients now and in the future.

Dr. Rob Schwartz – Director, Pre-Clinical Research

Dr. Rob SchwartzPre-clinical research is an essential step in the process of understanding the complexity and mechanisms of disease. This type of research allows scientists and clinicians to create models of disease states to uncover the behavioral and cellular processes responsible for the development of disease. As the precursors and course of action of a disease are more fully understood, pre-clinical research is then used to test and determine the safety and efficacy of treatment theories.

"As we strive to balance and integrate our work in basic and applied science, we will develop collaborative teams that bring a range of disciplines, technologies and perspectives to bear on critical clinically relevant issues," says Dr. Schwartz. "Effective teamwork represents our commitment to combining our knowledge and skills to serve our research community and industry clients, and to collaborate in the development and advancement of medical technology. Our relationships are built on professionalism, respect, and a commitment to supporting the innovation and advancement of medicine. We are excited to be a part of this new era in research at the Minneapolis Heart Institute Foundation and look forward to many years of working together to bring therapies from early stages of research to widespread availability for patients."


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